Factors Affecting Drug Dissolution from Solid Dispersion
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چکیده
منابع مشابه
Solid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...
متن کاملSolid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...
متن کاملFactors Affecting Dissolution Rate
Solubility of drug plays a prime role in controlling its dissolution from dosage form. Aqueous solubility of drug is a major factor that determines its dissolution rate. Minimum aqueous solubility of 1% is required to avoid potential solubility limited absorption problems. Studies of 45 compound of different chemical classes and a wide range of solubilities revealed that initial dissolution rat...
متن کاملsolid dispersion approach improving dissolution rate of stiripentol: a novel antiepileptic drug
some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. stiripentol (stp) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. it has poor aqueous solubilityand its solubility has to be enhanced accordingly. polyethyleneglycol 6000 (peg-6000) iscommonly utilized as a hydrophilic...
متن کاملStudies on dissolution enhancement of prednisolone, a poorly water-soluble drug by solid dispersion technique.
INTRODUCTION Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by a solid dispersion technique. METHODS Solid dispersion of prednisolone was prepared with PEG 6000 or different carbohydrates such as lactose a...
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ژورنال
عنوان ژورنال: Oleoscience
سال: 2017
ISSN: 1345-8949,2187-3461
DOI: 10.5650/oleoscience.17.373